�Researchers ar describing advance toward developing a newfangled generation of chemotherapy agents that quarry and choke up uncontrolled DNA replication - a assay-mark of cancer the Crab, viral infections, and other diseases - more in effect than stream drugs in ways that may grow fewer english effects. Their article is scheduled for the Aug. 27 issue of ACS' Biochemistry, a weekly daybook.
In the article, Anthony J. Berdis updates and reviews world-wide research efforts to develop drugs that target DNA polymerases, the enzymes responsible for for aggregation DNA from its constituent parts. Several promising strategies are already in use that inhibit uncontrolled DNA replication, particularly in antitumor therapy, simply most produce severe side of meat effects and are hampered by drug resistance, the researcher notes.
Berdis says that one of the more promising strategies to date involves the use of alleged nucleoside analogues, artificial pieces of DNA that inhibit replication by substituting for natural segments. Most nucleoside analogues direct target the active site of the polymerase enzyme, a nonspecific approach that can also harm tidy cells which contain the enzyme. Berdis describes an alternative glide path in which the drugs directly target damaged DNA while avoiding healthy DNA, side-stepping the polymerase enzymes of normal cells. The development, which shows promise in preliminary lab studies, could leading to improved nucleoside analogues with fewer side personal effects, he says. - MTS
"DNA Polymerases as Therapeutic Targets"
Biochemistry, 47 (32), 8253 - 8260, 2008. 10.1021/bi801179f
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American Chemical Society
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