�Researchers ar describing advance toward developing a newfangled generation of chemotherapy agents that quarry and choke up uncontrolled DNA replication - a assay-mark of cancer the Crab, viral infections, and other diseases - more in effect than stream drugs in ways that may grow fewer english effects. Their article is scheduled for the Aug. 27 issue of ACS' Biochemistry, a weekly daybook.
In the article, Anthony J. Berdis updates and reviews world-wide research efforts to develop drugs that target DNA polymerases, the enzymes responsible for for aggregation DNA from its constituent parts. Several promising strategies are already in use that inhibit uncontrolled DNA replication, particularly in antitumor therapy, simply most produce severe side of meat effects and are hampered by drug resistance, the researcher notes.
Berdis says that one of the more promising strategies to date involves the use of alleged nucleoside analogues, artificial pieces of DNA that inhibit replication by substituting for natural segments. Most nucleoside analogues direct target the active site of the polymerase enzyme, a nonspecific approach that can also harm tidy cells which contain the enzyme. Berdis describes an alternative glide path in which the drugs directly target damaged DNA while avoiding healthy DNA, side-stepping the polymerase enzymes of normal cells. The development, which shows promise in preliminary lab studies, could leading to improved nucleoside analogues with fewer side personal effects, he says. - MTS
"DNA Polymerases as Therapeutic Targets"
Biochemistry, 47 (32), 8253 - 8260, 2008. 10.1021/bi801179f
Download Full Text Article
American Chemical Society
More information
Tuesday, 9 September 2008
Saturday, 30 August 2008
Magnesium Sulphate May Reduce Cerebral Palsy
�Giving atomic number 12 sulphate to stop women from going into premature labour could reduce the chances of babies by and by being diagnosed with
moderate to austere cerebral palsy, said researchers in the US.
The multicenter, placebo-controlled, double blind trial was the work of Dr Dwight Rouse, from the University of Alabama at Birmingham, and
colleagues, and is promulgated in the 28 August online issue of the New England Journal of Medicine, NEJM.
For the research, Rouse and colleagues studied 2,241 women world Health Organization were at risk of going into premature labour between their 24th and 31st calendar week of
maternity. The women were indiscriminately assigned to receive either magnesium sulfate, given intravenously as a 6g bolus followed by a constant
infusion of 2g per hour, or a coordinated placebo.
Magnesium sulphate is used to slow down the contractions of the uterus and thereby detain labour.
The researchers followed the surviving babies for deuce years. They counted the number of stillbirths or babies that died ahead reaching 1 year of
corrected historic period, and they also counted the incidence of contain or severe cerebral palsy at or beyond 2 years of corrected age.
The results showed that:
95.6 per cent of the children were followed up.
Primary analysis did not show pregnant differences between the two groups in the combined risk of moderate or severe paralysis or death (11.3 per
penny in the treatment group, 11.7 per cent in the placebo group, with a relative hazard of 0.97).
Secondary analysis showed that mince or knockout cerebral palsy occurred significantly less frequently in the magnesium sulphate group (1.9 per
cent versus 3.5 per cent more cases in the placebo grouping, giving a relative risk of 0.55, ie 45 per cent less risk of moderate or severe cerebral palsy
in the treatment group).
The risk of infection of death was non significantly different between the groups.
Adverse events such as flushing and sweating were more common among the women in the handling group, and none of the women
experienced a life-threatening event.
The authors complete that:
"Fetal exposure to mg sulfate before anticipated other preterm bringing did not reduce the combined risk of hold or hard cerebral
paralysis or death, although the rate of cerebral palsy was reduced among survivors."
An editorial in the same issue of the journal said the study showed promising results but did not commend using atomic number 12 sulphate in anticipated
preterm labour as a way of life to prevent cerebral palsy.
The editors, who included Dr Fiona Stanley, from the University of Western Australia's Centre for Child Health Research, said that more research was
required that looked more intimately at the reasons for preterm birthing and the effects of timing (eg relative to pregnancy weeks and birth) and sizing of
atomic number 12 sulphate doses.
"A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy."
Rouse, Dwight J., Hirtz, Deborah G., Thom, Elizabeth, Varner, Michael W., Spong, Catherine Y., Mercer, Brian M., Iams, Jay D., Wapner, Ronald J.,
Sorokin, Yoram, Alexander, James M., Harper, Margaret, Thorp, John M., Jr., Ramin, Susan M., Malone, Fergal D., Carpenter, Marshall, Miodovnik,
Menachem, Moawad, Atef, O'Sullivan, Mary J., Peaceman, Alan M., Hankins, Gary D.V., Langer, Oded, Caritis, Steve N., Roberts, James M., the
Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network.
N Engl J Med 2008, 359: 895-905.
Volume 359; pages 895-905, published on-line August 28, 2008.
Click here for Abstract.
Sources: NEJM.
Written by: Catharine Paddock, PhD
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today
More information
moderate to austere cerebral palsy, said researchers in the US.
The multicenter, placebo-controlled, double blind trial was the work of Dr Dwight Rouse, from the University of Alabama at Birmingham, and
colleagues, and is promulgated in the 28 August online issue of the New England Journal of Medicine, NEJM.
For the research, Rouse and colleagues studied 2,241 women world Health Organization were at risk of going into premature labour between their 24th and 31st calendar week of
maternity. The women were indiscriminately assigned to receive either magnesium sulfate, given intravenously as a 6g bolus followed by a constant
infusion of 2g per hour, or a coordinated placebo.
Magnesium sulphate is used to slow down the contractions of the uterus and thereby detain labour.
The researchers followed the surviving babies for deuce years. They counted the number of stillbirths or babies that died ahead reaching 1 year of
corrected historic period, and they also counted the incidence of contain or severe cerebral palsy at or beyond 2 years of corrected age.
The results showed that:
95.6 per cent of the children were followed up.
Primary analysis did not show pregnant differences between the two groups in the combined risk of moderate or severe paralysis or death (11.3 per
penny in the treatment group, 11.7 per cent in the placebo group, with a relative hazard of 0.97).
Secondary analysis showed that mince or knockout cerebral palsy occurred significantly less frequently in the magnesium sulphate group (1.9 per
cent versus 3.5 per cent more cases in the placebo grouping, giving a relative risk of 0.55, ie 45 per cent less risk of moderate or severe cerebral palsy
in the treatment group).
The risk of infection of death was non significantly different between the groups.
Adverse events such as flushing and sweating were more common among the women in the handling group, and none of the women
experienced a life-threatening event.
The authors complete that:
"Fetal exposure to mg sulfate before anticipated other preterm bringing did not reduce the combined risk of hold or hard cerebral
paralysis or death, although the rate of cerebral palsy was reduced among survivors."
An editorial in the same issue of the journal said the study showed promising results but did not commend using atomic number 12 sulphate in anticipated
preterm labour as a way of life to prevent cerebral palsy.
The editors, who included Dr Fiona Stanley, from the University of Western Australia's Centre for Child Health Research, said that more research was
required that looked more intimately at the reasons for preterm birthing and the effects of timing (eg relative to pregnancy weeks and birth) and sizing of
atomic number 12 sulphate doses.
"A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy."
Rouse, Dwight J., Hirtz, Deborah G., Thom, Elizabeth, Varner, Michael W., Spong, Catherine Y., Mercer, Brian M., Iams, Jay D., Wapner, Ronald J.,
Sorokin, Yoram, Alexander, James M., Harper, Margaret, Thorp, John M., Jr., Ramin, Susan M., Malone, Fergal D., Carpenter, Marshall, Miodovnik,
Menachem, Moawad, Atef, O'Sullivan, Mary J., Peaceman, Alan M., Hankins, Gary D.V., Langer, Oded, Caritis, Steve N., Roberts, James M., the
Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network.
N Engl J Med 2008, 359: 895-905.
Volume 359; pages 895-905, published on-line August 28, 2008.
Click here for Abstract.
Sources: NEJM.
Written by: Catharine Paddock, PhD
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today
More information
Wednesday, 20 August 2008
The Hold Steady: 'Radiohead have lost the plot'
The Hold Steady's guitarist Tad Kubler has slammed Radiohead's revoluntionary pay what you want plan for their last album 'In Rainbows'.
The guitar player also criticised the band's experimental musical approach.
"I think they've lost the plot," he said. "What are they doing? Where are they going? What's happening? I don't aim it whatever more. They lost me.
"I quiet appreciate what they're doing, or what they're trying to do. But I think they're trying to a fault hard non to be Radiohead. That seems a little laughable to me."
"I like them as a rock dance orchestra, all the buttons and sequencing and stuff like that I don't truly care for. I'm a fan of rock music and what they're doing now I don't think is very good."
Kubler as well said Muse "don't do it for me" simply he praised Oasis.
He told BBC 6 Music: "I love Oasis. I erotic love them. I think that what they do is earnest. I think it's honest."
More info
The guitar player also criticised the band's experimental musical approach.
"I think they've lost the plot," he said. "What are they doing? Where are they going? What's happening? I don't aim it whatever more. They lost me.
"I quiet appreciate what they're doing, or what they're trying to do. But I think they're trying to a fault hard non to be Radiohead. That seems a little laughable to me."
"I like them as a rock dance orchestra, all the buttons and sequencing and stuff like that I don't truly care for. I'm a fan of rock music and what they're doing now I don't think is very good."
Kubler as well said Muse "don't do it for me" simply he praised Oasis.
He told BBC 6 Music: "I love Oasis. I erotic love them. I think that what they do is earnest. I think it's honest."
More info
Sunday, 10 August 2008
Shirley Collins and Davy Graham
Artist: Shirley Collins and Davy Graham
Genre(s):
Folk
Discography:
Folk Roots New Routes
Year: 2005
Tracks: 16
"Godfather" meets Macbeth in Saddam Hussein drama
Tuesday, 1 July 2008
Grand National
Artist: Grand National
Genre(s):
Rock
Other
Discography:
Drink and A Quick Decision
Year: 2007
Tracks: 12
Kicking the National Habit
Year: 2006
Tracks: 12
Thursday, 26 June 2008
Leona Lewis
Artist: Leona Lewis
Genre(s):
Pop
Discography:
Spirit
Year: 2007
Tracks: 14
A impinging young adult female with a strong vocal resemblance to the young Whitney Houston and pop music's largest mop of blond bottle screw curls since Twisted Sister's Dee Snider circa "We're Not Gonna Take It," Leona Lewis won the third series of the British reality talent indicate The X Factor in a landslip. (For non-Brits: The X Factor is the revamped followup to the original U.K. talent search, Pop Idol, of which American Idol is the massively successful U.S. version; AI's Simon Cowell is the show's Born and elevated in the Islington section of north London, Lewis won a talent indicate at the BRIT School for Performing Arts and Technology. While Lewis auditioned for The X Factor in the summer of 2006 and won the tierce series competition in December of that Lewis' debut single, a soulful cover of Kelly Clarkson's "A Moment Like This" (Clarkson's have debut American Idol display case single), was the numeral one single in the U.K. at the plough of the year, including the coveted "Noel Number One." Along with her TV-driven U.K. winner, Leona Lewis sign an American recording carry on with Clive Davis' J Records in February 2007, with plans to U.S. telly debut on the 2007 season of Idol.
Monday, 16 June 2008
The 5 minute interview
CALIFORNIAN singer- songwriter Sara Bareilles scored a Top 5 hit in the US
with her piano-soul pop single Love Song. Here, she chats to JACQUI SWIFT
about her music in our new regular quickfire Q&A.
WHEN did you start singing?
I started through community theatre in Eureka, California when I was ten or
11. I was then singing in schools and in choirs. In my early 20s I started
recording for an indie label before being signed to Epic in America.
Who are your influences?
Elton John, Billy Joel. Fiona Apple, Aretha Franklin, Ray Charles and Etta
James. And Counting Crows, Ben Folds and Radiohead.
Tell us about Love Song . . .
It was written when I felt I was going nowhere as I was more concerned with
what others thought. This p***** me off – that is how Love Song came about.
It is a very honest song that people connect with. It’s also very upbeat.
How important was getting a TV advert in the US for the song?
It was so important. I didn’t realise it at the time but it made a huge
difference, the synergy with the ad saw the song climbing up the charts.
Your songs are autobiographical. What did the people involved think about
them?
In my relationship to those songs they are about specific people. They know
who they are. I always say you can’t expect to date a songwriter and not
expect to show up in the songs.
You say recording your album Little Voice was stressful. Why?
I felt like I was taking the first steps in defining who I would be in the
musical landscape of things. At the time it seemed like a heavy project I
was part of.
How do you feel about being compared to Fiona Apple, Norah Jones and Sheryl
Crow?
They’re good to be compared with. They have longevity in their careers and
make diverse music.
Being a female singer-songwriter do you feel pressured to have a certain
image?
Definitely. The pressure to be model skinny and picture perfect. You cope by
staying grounded and staying away from the Hollywoodness of it all as it is
toxic and completely false.
What does the rest of the year hold for you?
At the end of the month I tour with Maroon 5 which will be a lot of fun. We’re
friends. There are plans for my own European tour this fall so I’ll be back
real soon.
Sara plays London’s Bush Hall on Monday.
with her piano-soul pop single Love Song. Here, she chats to JACQUI SWIFT
about her music in our new regular quickfire Q&A.
WHEN did you start singing?
I started through community theatre in Eureka, California when I was ten or
11. I was then singing in schools and in choirs. In my early 20s I started
recording for an indie label before being signed to Epic in America.
Who are your influences?
Elton John, Billy Joel. Fiona Apple, Aretha Franklin, Ray Charles and Etta
James. And Counting Crows, Ben Folds and Radiohead.
Tell us about Love Song . . .
It was written when I felt I was going nowhere as I was more concerned with
what others thought. This p***** me off – that is how Love Song came about.
It is a very honest song that people connect with. It’s also very upbeat.
How important was getting a TV advert in the US for the song?
It was so important. I didn’t realise it at the time but it made a huge
difference, the synergy with the ad saw the song climbing up the charts.
Your songs are autobiographical. What did the people involved think about
them?
In my relationship to those songs they are about specific people. They know
who they are. I always say you can’t expect to date a songwriter and not
expect to show up in the songs.
You say recording your album Little Voice was stressful. Why?
I felt like I was taking the first steps in defining who I would be in the
musical landscape of things. At the time it seemed like a heavy project I
was part of.
How do you feel about being compared to Fiona Apple, Norah Jones and Sheryl
Crow?
They’re good to be compared with. They have longevity in their careers and
make diverse music.
Being a female singer-songwriter do you feel pressured to have a certain
image?
Definitely. The pressure to be model skinny and picture perfect. You cope by
staying grounded and staying away from the Hollywoodness of it all as it is
toxic and completely false.
What does the rest of the year hold for you?
At the end of the month I tour with Maroon 5 which will be a lot of fun. We’re
friends. There are plans for my own European tour this fall so I’ll be back
real soon.
Sara plays London’s Bush Hall on Monday.
Sunday, 8 June 2008
Estelle is Mica's British girl
MICA PARIS has invited ESTELLE to perform alongside her in London later this
year.
The What Not To Wear presenter is doing a series of six shows later this year
at the IndigO2 venue. She'll be singing alongside such legends as PRINCE,
JAY Z and CHAKA KHAN.
But she took a special shine to the American Boy singer, telling her: "You
have to come and do a show with me."
The pair of songbirds chatted happily to each other at the Martini Rosato
party at The Roof Gardens in Kensington, West London.
Estelle was equally gushing as she agreed to do the gig, saying: "You
were my inspiration to get into music."
year.
The What Not To Wear presenter is doing a series of six shows later this year
at the IndigO2 venue. She'll be singing alongside such legends as PRINCE,
JAY Z and CHAKA KHAN.
But she took a special shine to the American Boy singer, telling her: "You
have to come and do a show with me."
The pair of songbirds chatted happily to each other at the Martini Rosato
party at The Roof Gardens in Kensington, West London.
Estelle was equally gushing as she agreed to do the gig, saying: "You
were my inspiration to get into music."
Friday, 30 May 2008
Kiss - Kiss Meet Condoleeza
Legendary glam rockers KISS spoke about world affairs in an unexpected late-night meeting with U.S. politician CONDOLEEZA RICE.
Secretary of State Rice learned she was sharing a hotel with the rockers after bumping into them in the executive lounge of the Sheraton Hotel in Stockholm, Sweden on Thursday (29May08).
Rice was in the city for an international conference on Iraq, while the metal quartet was in town to play a sold-out gig on Friday (30May08).
Rice revealed the band is up-to-date on current events - and even asked her if they could meet again after she finished her dinner meeting with the Swedish foreign minister. Rice agreed to their request.
She says, "I was thrilled. It was really fun to meet Kiss and Gene Simmons."
See Also
Tuesday, 27 May 2008
Charlton Heston - The Ten Commandments Tablets To Be Sold At Auction
CHARLTON HESTON's most iconic movie treasures are to auctioned off as part of a massive memorabilia sale later this summer (08).
Tablets from The Ten Commandments and the kaftan and pallium the late Heston wore in Ben Hur are among the items which will go under the hammer at the upcoming Profiles in History auction in Los Angeles on 31 July (08) and 1 August (08).
The Ten Commandments tablets, which are expected to fetch upto $60,000 (GBP30,000), were one of four used in the 1956 movie classic, and are considered to be the best preserved.
They were given to The Sands Hotel in Atlantic City, New Jersey, where they have been on display for many years.
A spokesman for Profiles In History says, "These tablets retain the beautiful red and black-speckled patina of the Mount Sinaiinspired granite, with translucent white engraved letters and nearly pristine edges.
"There are few props in the history of film that are so easily recognisable, and so coveted by seasoned collectors of original Hollywood film relics. Overall the tablets remain in exceptional condition."
Meanwhile, Heston's Ben Hur costume is expected to fetch more than $12,000 (GBP6,000).
The two lots are part of a 1,000 item haul, offered as part of Profiles in History's 32nd auction of Hollywood memorabilia.
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Shia LaBeouf on Rihanna romance rumors: “I really don’t know her like that”
Shia LaBeouf has revealed that when rumors surfaced that he was dating Rihanna last year, he had to endure weeks of listening to his friends humming the singer’s biggest hit: Umbrella.
“My friends were like, ‘Are you serious, bro? Why didn’t you tell me about that?’ I was like, ‘I really don’t know her like that.’
“For weeks they were singing that “Umbrella” song everywhere I walked. And those are my people!” he tells GQ magazine.
LaBeouf, 21, also that when it came to preparing for his new movie Indiana Jones and the Kingdom of the Crystal Skull — in which the actor stars as Mutt Williams alongside Harrison Ford — he “never worked so hard for anything in my life. I did four months of sword fighting and bike training. And I spent insane amounts of time on the switchblade.”
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Jolie shows off baby bump at awards
Actress Angelina Jolie revealed her baby bump at the Independent Spirit Awards after previously dismissing media speculation about a pregnancy.
The star caused a stir when she arrived at the film event wearing a figure-hugging black dress, revealing an obvious baby bump.
A source close to the actress and her partner Brad Pitt reportedly told People magazine that the couple are "thrilled to be adding to their brood".
Jolie and Pitt already have four children, six-year-old Maddox, four-year-old Pax, three-year-old Zahara and one-year-old Shiloh.
The star caused a stir when she arrived at the film event wearing a figure-hugging black dress, revealing an obvious baby bump.
A source close to the actress and her partner Brad Pitt reportedly told People magazine that the couple are "thrilled to be adding to their brood".
Jolie and Pitt already have four children, six-year-old Maddox, four-year-old Pax, three-year-old Zahara and one-year-old Shiloh.
Narnia gets feminist makeover in Prince Caspian
Altering a much-loved book for the big screen is a bold move.
Paramount to launch Spanish operation
Signs 12-picture deal with A. Zeta banner
CANNES -- Paramount Pictures International is ramping up its overseas activities with the launch of a Spanish operation and a 12-picture theatrical output deal with veteran producer Andres Vicente Gomez and his A. Zeta banner.
The move by the Hollywood major is part of its ongoing initiative to set up standalone distribution outfits in key territories around the globe in the wake of its split from UIP two years ago. A similar operation will be set up in Germany in January 2009.
The 12 handpicked titles from Gomez are split between six U.S. pick-ups and six Spanish productions. First out of the block will be "Manolete," starring Adrien Brody and Penelope Cruz.
Highlights from the U.S. half dozen include "Young People Fucking," "She Found Me" and "Before the Devil Knows You're Dead."
PPI's Spanish operation, which will be up and running this July, will be headed by former Paramount Home Entertainment marketing chief in Madrid Pierre Auger, PPI president Andrew Cripps said. Cripps told THR that the deal with Gomez was central to the company's ambitions. He said that PPI has sat down with Gomez and his team to choose the films PPI could do well with theatrically.
"We are hoping that this relationship becomes a long-term thing," Cripps said. "We're delighted to have this deal in place right before we even open our offices in Spain."
PPI's new office in Spain follows the carve-up of UIP's distribution network, in which the two U.S. majors split key European territories when UIP broke up in 2006.
"This is part of our strategy as we set up international offices. We want to be in business with local filmmakers, and Gomez is one of the best," Cripps explained.
The local Par outfit is expected to get into business with other Spanish producers once the operation is up and running.
A. Zeta signed a distribution pact with Universal in September 2007 to handle video and DVD distribution that won't be immediately affected by the pact with PPI.
Gomez is one of Spain's most established producers, with past credits including "Belle Epoque," "The Dancer Upstairs" and "The Common Wealth."
A major figure on the Spanish scene, Gomez has recently jumped on the 3-D bandwagon, with a 40 million euros animated musical feature called "Genies," which forms part of the PPI theatrical deal.
"Genies" is set up at Gomez's RadioPlus production house, a company he co-owns with Spanish journalist Concha Garcia-Campoy. India's Toonz Animation and Saudi Arabia's Kingdom TV are backing the project.
"I'm getting more interested in animation," Gomez said. "The project was inspired by Saudi Arabia's King Abdullah National Gardens."
"Genies" enters the fantasy world of Geniland that encompasses all civilizations, with original versions being produced in English, Spanish and Hindi.
See Also
Irish short is chosen for Sundance
The Irish short film 'The Sound of People' has been selected to screen as part of the programme for the world famous Sundance Film Festival in the US.
The Simon Fitzmaurice-directed film is the only Irish short to be chosen for the International Dramatic Shorts programme at the festival in Park City, Utah next month.
Only 19 films in total have been chosen for the International Dramatic Shorts programme.
'The Sound of People' stars Belfast actor Martin McCann as Stephen, an 18-year-old who travels into his past and future in the space of a moment.
Commenting on the film's selection, writer-director Fitzmaurice said: "I am absolutely over the moon about getting into Sundance. Everyone worked heart and soul on this film and this is a wonderful response."
The Sundance Film Festival runs from 17 to 27 January 2008; the new Brendan Gleeson and Colin Farrell-starring film 'In Bruges' will open the festival.
The Simon Fitzmaurice-directed film is the only Irish short to be chosen for the International Dramatic Shorts programme at the festival in Park City, Utah next month.
Only 19 films in total have been chosen for the International Dramatic Shorts programme.
'The Sound of People' stars Belfast actor Martin McCann as Stephen, an 18-year-old who travels into his past and future in the space of a moment.
Commenting on the film's selection, writer-director Fitzmaurice said: "I am absolutely over the moon about getting into Sundance. Everyone worked heart and soul on this film and this is a wonderful response."
The Sundance Film Festival runs from 17 to 27 January 2008; the new Brendan Gleeson and Colin Farrell-starring film 'In Bruges' will open the festival.
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