�Researchers ar describing advance toward developing a newfangled generation of chemotherapy agents that quarry and choke up uncontrolled DNA replication - a assay-mark of cancer the Crab, viral infections, and other diseases - more in effect than stream drugs in ways that may grow fewer english effects. Their article is scheduled for the Aug. 27 issue of ACS' Biochemistry, a weekly daybook.
In the article, Anthony J. Berdis updates and reviews world-wide research efforts to develop drugs that target DNA polymerases, the enzymes responsible for for aggregation DNA from its constituent parts. Several promising strategies are already in use that inhibit uncontrolled DNA replication, particularly in antitumor therapy, simply most produce severe side of meat effects and are hampered by drug resistance, the researcher notes.
Berdis says that one of the more promising strategies to date involves the use of alleged nucleoside analogues, artificial pieces of DNA that inhibit replication by substituting for natural segments. Most nucleoside analogues direct target the active site of the polymerase enzyme, a nonspecific approach that can also harm tidy cells which contain the enzyme. Berdis describes an alternative glide path in which the drugs directly target damaged DNA while avoiding healthy DNA, side-stepping the polymerase enzymes of normal cells. The development, which shows promise in preliminary lab studies, could leading to improved nucleoside analogues with fewer side personal effects, he says. - MTS
"DNA Polymerases as Therapeutic Targets"
Biochemistry, 47 (32), 8253 - 8260, 2008. 10.1021/bi801179f
Download Full Text Article
American Chemical Society
More information
Tuesday, 9 September 2008
Saturday, 30 August 2008
Magnesium Sulphate May Reduce Cerebral Palsy
�Giving atomic number 12 sulphate to stop women from going into premature labour could reduce the chances of babies by and by being diagnosed with
moderate to austere cerebral palsy, said researchers in the US.
The multicenter, placebo-controlled, double blind trial was the work of Dr Dwight Rouse, from the University of Alabama at Birmingham, and
colleagues, and is promulgated in the 28 August online issue of the New England Journal of Medicine, NEJM.
For the research, Rouse and colleagues studied 2,241 women world Health Organization were at risk of going into premature labour between their 24th and 31st calendar week of
maternity. The women were indiscriminately assigned to receive either magnesium sulfate, given intravenously as a 6g bolus followed by a constant
infusion of 2g per hour, or a coordinated placebo.
Magnesium sulphate is used to slow down the contractions of the uterus and thereby detain labour.
The researchers followed the surviving babies for deuce years. They counted the number of stillbirths or babies that died ahead reaching 1 year of
corrected historic period, and they also counted the incidence of contain or severe cerebral palsy at or beyond 2 years of corrected age.
The results showed that:
95.6 per cent of the children were followed up.
Primary analysis did not show pregnant differences between the two groups in the combined risk of moderate or severe paralysis or death (11.3 per
penny in the treatment group, 11.7 per cent in the placebo group, with a relative hazard of 0.97).
Secondary analysis showed that mince or knockout cerebral palsy occurred significantly less frequently in the magnesium sulphate group (1.9 per
cent versus 3.5 per cent more cases in the placebo grouping, giving a relative risk of 0.55, ie 45 per cent less risk of moderate or severe cerebral palsy
in the treatment group).
The risk of infection of death was non significantly different between the groups.
Adverse events such as flushing and sweating were more common among the women in the handling group, and none of the women
experienced a life-threatening event.
The authors complete that:
"Fetal exposure to mg sulfate before anticipated other preterm bringing did not reduce the combined risk of hold or hard cerebral
paralysis or death, although the rate of cerebral palsy was reduced among survivors."
An editorial in the same issue of the journal said the study showed promising results but did not commend using atomic number 12 sulphate in anticipated
preterm labour as a way of life to prevent cerebral palsy.
The editors, who included Dr Fiona Stanley, from the University of Western Australia's Centre for Child Health Research, said that more research was
required that looked more intimately at the reasons for preterm birthing and the effects of timing (eg relative to pregnancy weeks and birth) and sizing of
atomic number 12 sulphate doses.
"A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy."
Rouse, Dwight J., Hirtz, Deborah G., Thom, Elizabeth, Varner, Michael W., Spong, Catherine Y., Mercer, Brian M., Iams, Jay D., Wapner, Ronald J.,
Sorokin, Yoram, Alexander, James M., Harper, Margaret, Thorp, John M., Jr., Ramin, Susan M., Malone, Fergal D., Carpenter, Marshall, Miodovnik,
Menachem, Moawad, Atef, O'Sullivan, Mary J., Peaceman, Alan M., Hankins, Gary D.V., Langer, Oded, Caritis, Steve N., Roberts, James M., the
Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network.
N Engl J Med 2008, 359: 895-905.
Volume 359; pages 895-905, published on-line August 28, 2008.
Click here for Abstract.
Sources: NEJM.
Written by: Catharine Paddock, PhD
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today
More information
moderate to austere cerebral palsy, said researchers in the US.
The multicenter, placebo-controlled, double blind trial was the work of Dr Dwight Rouse, from the University of Alabama at Birmingham, and
colleagues, and is promulgated in the 28 August online issue of the New England Journal of Medicine, NEJM.
For the research, Rouse and colleagues studied 2,241 women world Health Organization were at risk of going into premature labour between their 24th and 31st calendar week of
maternity. The women were indiscriminately assigned to receive either magnesium sulfate, given intravenously as a 6g bolus followed by a constant
infusion of 2g per hour, or a coordinated placebo.
Magnesium sulphate is used to slow down the contractions of the uterus and thereby detain labour.
The researchers followed the surviving babies for deuce years. They counted the number of stillbirths or babies that died ahead reaching 1 year of
corrected historic period, and they also counted the incidence of contain or severe cerebral palsy at or beyond 2 years of corrected age.
The results showed that:
95.6 per cent of the children were followed up.
Primary analysis did not show pregnant differences between the two groups in the combined risk of moderate or severe paralysis or death (11.3 per
penny in the treatment group, 11.7 per cent in the placebo group, with a relative hazard of 0.97).
Secondary analysis showed that mince or knockout cerebral palsy occurred significantly less frequently in the magnesium sulphate group (1.9 per
cent versus 3.5 per cent more cases in the placebo grouping, giving a relative risk of 0.55, ie 45 per cent less risk of moderate or severe cerebral palsy
in the treatment group).
The risk of infection of death was non significantly different between the groups.
Adverse events such as flushing and sweating were more common among the women in the handling group, and none of the women
experienced a life-threatening event.
The authors complete that:
"Fetal exposure to mg sulfate before anticipated other preterm bringing did not reduce the combined risk of hold or hard cerebral
paralysis or death, although the rate of cerebral palsy was reduced among survivors."
An editorial in the same issue of the journal said the study showed promising results but did not commend using atomic number 12 sulphate in anticipated
preterm labour as a way of life to prevent cerebral palsy.
The editors, who included Dr Fiona Stanley, from the University of Western Australia's Centre for Child Health Research, said that more research was
required that looked more intimately at the reasons for preterm birthing and the effects of timing (eg relative to pregnancy weeks and birth) and sizing of
atomic number 12 sulphate doses.
"A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy."
Rouse, Dwight J., Hirtz, Deborah G., Thom, Elizabeth, Varner, Michael W., Spong, Catherine Y., Mercer, Brian M., Iams, Jay D., Wapner, Ronald J.,
Sorokin, Yoram, Alexander, James M., Harper, Margaret, Thorp, John M., Jr., Ramin, Susan M., Malone, Fergal D., Carpenter, Marshall, Miodovnik,
Menachem, Moawad, Atef, O'Sullivan, Mary J., Peaceman, Alan M., Hankins, Gary D.V., Langer, Oded, Caritis, Steve N., Roberts, James M., the
Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network.
N Engl J Med 2008, 359: 895-905.
Volume 359; pages 895-905, published on-line August 28, 2008.
Click here for Abstract.
Sources: NEJM.
Written by: Catharine Paddock, PhD
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today
More information
Wednesday, 20 August 2008
The Hold Steady: 'Radiohead have lost the plot'
The Hold Steady's guitarist Tad Kubler has slammed Radiohead's revoluntionary pay what you want plan for their last album 'In Rainbows'.
The guitar player also criticised the band's experimental musical approach.
"I think they've lost the plot," he said. "What are they doing? Where are they going? What's happening? I don't aim it whatever more. They lost me.
"I quiet appreciate what they're doing, or what they're trying to do. But I think they're trying to a fault hard non to be Radiohead. That seems a little laughable to me."
"I like them as a rock dance orchestra, all the buttons and sequencing and stuff like that I don't truly care for. I'm a fan of rock music and what they're doing now I don't think is very good."
Kubler as well said Muse "don't do it for me" simply he praised Oasis.
He told BBC 6 Music: "I love Oasis. I erotic love them. I think that what they do is earnest. I think it's honest."
More info
The guitar player also criticised the band's experimental musical approach.
"I think they've lost the plot," he said. "What are they doing? Where are they going? What's happening? I don't aim it whatever more. They lost me.
"I quiet appreciate what they're doing, or what they're trying to do. But I think they're trying to a fault hard non to be Radiohead. That seems a little laughable to me."
"I like them as a rock dance orchestra, all the buttons and sequencing and stuff like that I don't truly care for. I'm a fan of rock music and what they're doing now I don't think is very good."
Kubler as well said Muse "don't do it for me" simply he praised Oasis.
He told BBC 6 Music: "I love Oasis. I erotic love them. I think that what they do is earnest. I think it's honest."
More info
Sunday, 10 August 2008
Shirley Collins and Davy Graham
Artist: Shirley Collins and Davy Graham
Genre(s):
Folk
Discography:
Folk Roots New Routes
Year: 2005
Tracks: 16
"Godfather" meets Macbeth in Saddam Hussein drama
Tuesday, 1 July 2008
Grand National
Artist: Grand National
Genre(s):
Rock
Other
Discography:
Drink and A Quick Decision
Year: 2007
Tracks: 12
Kicking the National Habit
Year: 2006
Tracks: 12
Thursday, 26 June 2008
Leona Lewis
Artist: Leona Lewis
Genre(s):
Pop
Discography:
Spirit
Year: 2007
Tracks: 14
A impinging young adult female with a strong vocal resemblance to the young Whitney Houston and pop music's largest mop of blond bottle screw curls since Twisted Sister's Dee Snider circa "We're Not Gonna Take It," Leona Lewis won the third series of the British reality talent indicate The X Factor in a landslip. (For non-Brits: The X Factor is the revamped followup to the original U.K. talent search, Pop Idol, of which American Idol is the massively successful U.S. version; AI's Simon Cowell is the show's Born and elevated in the Islington section of north London, Lewis won a talent indicate at the BRIT School for Performing Arts and Technology. While Lewis auditioned for The X Factor in the summer of 2006 and won the tierce series competition in December of that Lewis' debut single, a soulful cover of Kelly Clarkson's "A Moment Like This" (Clarkson's have debut American Idol display case single), was the numeral one single in the U.K. at the plough of the year, including the coveted "Noel Number One." Along with her TV-driven U.K. winner, Leona Lewis sign an American recording carry on with Clive Davis' J Records in February 2007, with plans to U.S. telly debut on the 2007 season of Idol.
Monday, 16 June 2008
The 5 minute interview
CALIFORNIAN singer- songwriter Sara Bareilles scored a Top 5 hit in the US
with her piano-soul pop single Love Song. Here, she chats to JACQUI SWIFT
about her music in our new regular quickfire Q&A.
WHEN did you start singing?
I started through community theatre in Eureka, California when I was ten or
11. I was then singing in schools and in choirs. In my early 20s I started
recording for an indie label before being signed to Epic in America.
Who are your influences?
Elton John, Billy Joel. Fiona Apple, Aretha Franklin, Ray Charles and Etta
James. And Counting Crows, Ben Folds and Radiohead.
Tell us about Love Song . . .
It was written when I felt I was going nowhere as I was more concerned with
what others thought. This p***** me off – that is how Love Song came about.
It is a very honest song that people connect with. It’s also very upbeat.
How important was getting a TV advert in the US for the song?
It was so important. I didn’t realise it at the time but it made a huge
difference, the synergy with the ad saw the song climbing up the charts.
Your songs are autobiographical. What did the people involved think about
them?
In my relationship to those songs they are about specific people. They know
who they are. I always say you can’t expect to date a songwriter and not
expect to show up in the songs.
You say recording your album Little Voice was stressful. Why?
I felt like I was taking the first steps in defining who I would be in the
musical landscape of things. At the time it seemed like a heavy project I
was part of.
How do you feel about being compared to Fiona Apple, Norah Jones and Sheryl
Crow?
They’re good to be compared with. They have longevity in their careers and
make diverse music.
Being a female singer-songwriter do you feel pressured to have a certain
image?
Definitely. The pressure to be model skinny and picture perfect. You cope by
staying grounded and staying away from the Hollywoodness of it all as it is
toxic and completely false.
What does the rest of the year hold for you?
At the end of the month I tour with Maroon 5 which will be a lot of fun. We’re
friends. There are plans for my own European tour this fall so I’ll be back
real soon.
Sara plays London’s Bush Hall on Monday.
with her piano-soul pop single Love Song. Here, she chats to JACQUI SWIFT
about her music in our new regular quickfire Q&A.
WHEN did you start singing?
I started through community theatre in Eureka, California when I was ten or
11. I was then singing in schools and in choirs. In my early 20s I started
recording for an indie label before being signed to Epic in America.
Who are your influences?
Elton John, Billy Joel. Fiona Apple, Aretha Franklin, Ray Charles and Etta
James. And Counting Crows, Ben Folds and Radiohead.
Tell us about Love Song . . .
It was written when I felt I was going nowhere as I was more concerned with
what others thought. This p***** me off – that is how Love Song came about.
It is a very honest song that people connect with. It’s also very upbeat.
How important was getting a TV advert in the US for the song?
It was so important. I didn’t realise it at the time but it made a huge
difference, the synergy with the ad saw the song climbing up the charts.
Your songs are autobiographical. What did the people involved think about
them?
In my relationship to those songs they are about specific people. They know
who they are. I always say you can’t expect to date a songwriter and not
expect to show up in the songs.
You say recording your album Little Voice was stressful. Why?
I felt like I was taking the first steps in defining who I would be in the
musical landscape of things. At the time it seemed like a heavy project I
was part of.
How do you feel about being compared to Fiona Apple, Norah Jones and Sheryl
Crow?
They’re good to be compared with. They have longevity in their careers and
make diverse music.
Being a female singer-songwriter do you feel pressured to have a certain
image?
Definitely. The pressure to be model skinny and picture perfect. You cope by
staying grounded and staying away from the Hollywoodness of it all as it is
toxic and completely false.
What does the rest of the year hold for you?
At the end of the month I tour with Maroon 5 which will be a lot of fun. We’re
friends. There are plans for my own European tour this fall so I’ll be back
real soon.
Sara plays London’s Bush Hall on Monday.
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